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Canonical Wnt Signaling Pathway02:54

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Notch Signaling Pathway03:14

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Wnt signalling in neuronal differentiation and development.

Nibaldo C Inestrosa1, Lorena Varela-Nallar

  • 1Centro de Envejecimiento y Regeneración (CARE), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, 340, P. O. Box 114-D, Santiago, Chile, ninestrosa@bio.puc.cl.

Cell and Tissue Research
|September 20, 2014
PubMed
Summary

Wnt signaling proteins are crucial for neural development, guiding cell differentiation, migration, and circuit formation from early development through adulthood. This review highlights Wnt

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Wnt proteins are secreted glycoproteins essential for cellular processes.
  • Wnt signaling pathways regulate cell differentiation, migration, and development.
  • These pathways are critical from embryonic development through adulthood.

Purpose of the Study:

  • To review the diverse roles of Wnt signaling cascades in neural development.
  • To emphasize the specific functions of Wnts in neuronal differentiation and development.

Main Methods:

  • Literature review of studies on Wnt signaling in neural development.
  • Synthesis of findings on Wnt roles in progenitor cell differentiation, neural circuit formation, and adult brain plasticity.

Main Results:

  • Wnt gradients guide neural progenitor cell differentiation and migration.
  • Wnt signaling is involved in dendrite and axon development, spine formation, and synaptogenesis.
  • In adult brains, Wnts regulate hippocampal plasticity, synaptic transmission, and neurogenesis.

Conclusions:

  • Wnt signaling pathways are fundamental to neural development across all stages.
  • Understanding Wnt functions is key to comprehending neuronal differentiation and circuit formation.