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Neurodevelopmental long-term outcome in children after hemolytic uremic syndrome

Kathrin Buder1, Beatrice Latal, Samuel Nef

  • 1Pediatric Nephrology Unit, University Children's Hospital, Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland.

Pediatric Nephrology (Berlin, Germany)
|September 20, 2014
PubMed

Insights

Children with hemolytic uremic syndrome (HUS) show normal cognitive function long-term. However, neuromotor skills are impaired, regardless of central nervous system (CNS) involvement during HUS.

Area of Science:

  • Pediatric Neurology
  • Nephrology
  • Neurodevelopmental Disorders

Background:

  • Hemolytic uremic syndrome (HUS) is a serious condition affecting children.
  • Long-term neurodevelopmental outcomes after HUS require further investigation.
  • Understanding the impact of central nervous system (CNS) involvement during HUS is crucial.

Purpose of the Study:

  • To assess the long-term neurodevelopmental outcomes in children following HUS.
  • To compare neurodevelopmental outcomes based on the presence of CNS involvement during the acute phase of HUS.

Main Methods:

  • Retrospective cohort study of 47 children with a history of HUS.
  • Neurodevelopmental assessment included cognitive (Wechsler Intelligence Scale) and neuromotor (Zurich Neuromotor Assessment) evaluations.
  • Evaluation of neurological symptoms during the acute phase of HUS.

Main Results:

  • The study population exhibited normal mean full-scale IQ scores.
  • Significant impairments were observed in adaptive fine motor, gross motor, static balance, and associated movements.
  • No significant difference in neurodevelopmental outcomes was found between children with and without CNS involvement during HUS.

Conclusions:

  • Children recovering from HUS demonstrate favorable cognitive outcomes.
  • Neuromotor deficits are a common long-term consequence of HUS in children.
  • Acute CNS involvement during HUS does not predict long-term neurodevelopmental outcomes.
Abstract

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