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Fatal intoxication by Remoxipride
M Segerberg-Konttinen1, E Vuori, I Lukkari
1Department of Forensic Medicine, University of Helsinki, Finland.
Journal of Forensic Sciences
|March 1, 1989
Summary
This case study details a fatal Remoxipride overdose in a young woman. Blood Remoxipride levels were significantly higher than therapeutic ranges, indicating acute intoxication as the cause of death.
Area of Science:
- Toxicology
- Pharmacology
- Forensic Science
Background:
- Remoxipride is a novel benzamide neuroleptic.
- Understanding Remoxipride's toxicological profile is crucial for forensic analysis.
Observation:
- A 23-year-old female died by suicide using Remoxipride.
- Remoxipride was identified in post-mortem samples including liver, stomach contents, blood, and urine.
Findings:
- Blood Remoxipride concentration was 230 mg/L, vastly exceeding the recommended therapeutic range of 7-8 mg/L.
- No blood alcohol was detected; however, urine ethanol concentration was 0.048 g/100 L.
Implications:
- This case highlights the potential lethality of Remoxipride overdose.
- The exact mechanism of death from Remoxipride intoxication remains undetermined, warranting further investigation into its cardiotoxic effects observed in clinical studies (sinus bradycardia, ectopic beats).