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Related Experiment Video

Updated: Apr 23, 2026

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
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A hybrid mock circulation loop for a total artificial heart.

Frank Nestler1, Andrew P Bradley, Stephen J Wilson

  • 1School of Information Technology and Electrical Engineering, The University of Queensland, St. Lucia; ICET Lab, Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia; The Texas Heart Institute, Houston, TX, USA.

Artificial Organs
|September 20, 2014
PubMed
Summary

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A new hybrid mock circulation loop (HMCL) enables faster evaluation of rotary total artificial hearts (rTAH). This system combines physical pump testing with in silico vasculature for improved control and flexibility in device development.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Engineering
  • Medical Devices

Background:

  • Rotary blood pumps are advancing total artificial heart (TAH) technology.
  • Developing effective physiological control algorithms for TAHs requires sophisticated evaluation environments.

Purpose of the Study:

  • To introduce a novel hybrid mock circulation loop (HMCL) specifically designed for evaluating rotary total artificial hearts (rTAH).
  • To combine the advantages of physical testing with in silico modeling for enhanced TAH evaluation.

Main Methods:

  • The HMCL operates the rTAH in the physical domain while simulating vasculature in the numerical domain.
  • A hydraulic-numeric interface establishes a real-time feedback loop.
  • Computer-controlled resistance valves act as actuators, simplifying the system.
Keywords:
Hardware-in-the-loopMechanical circulatory supportMock circulation loopRotary blood pumpsTotal artificial heartVentricular assist device

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Related Experiment Videos

Last Updated: Apr 23, 2026

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Implantation of the Syncardia Total Artificial Heart
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Implantation of the Syncardia Total Artificial Heart

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Implantation of Total Artificial Heart in Congenital Heart Disease
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Main Results:

  • The HMCL demonstrated stable interaction across a broad operational range.
  • The system offers a high degree of flexibility for parameter variation (vascular resistance, compliance, blood volume) in silico.
  • The hybrid approach successfully integrates physical and numerical components.

Conclusions:

  • The developed HMCL is a valuable design environment for rTAH hydraulic design.
  • It facilitates control development and durability testing for rotary total artificial hearts.
  • This novel approach accelerates the advancement of TAH technology.