Oxidative stability of DHA phenolic ester
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Updated: Apr 23, 2026

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids
Published on: June 28, 2019
Mohamed H H Roby1, Vanessa C De Castro2, Brenda N Targino2
1Université de Lorraine, Laboratoire Ingénierie des Biomolécules (LIBio), 2 av. de la Forêt d'Haye, TSA 40602, 54518 Vandoeuvre Cedex, France; Fayoum University, Food Science and Technology Dept., Faculty of Agriculture, 63514 Fayoum, Egypt.
Abstract:
Docosahexaenoic acid vanillyl ester (DHA-VE) was synthesized from docosahexaenoic acid ethyl ester (DHA-EE) and vanillyl alcohol by a solvent-free alcoholysis process catalysed by Candida antarctica lipase B. Oxidative stability of pure DHA-VE and the crude reaction medium consisting of 45% DHA-VE and 55% DHA-EE were compared with that of DHA-EE under various storage conditions. Oxidation progress was followed by determination of conjugated dienes and FTIR measurements. Analyses showed that DHA-EE was rapidly oxidised under all storage conditions in comparison with DHA-VE and crude reaction medium, whatever the temperature and the storage time. The grafting of vanillyl alcohol appeared as a powerful way to stabilize DHA against oxidation. Thanks to their stability, both DHA-VE and the crude reaction medium, allowing the production of the ester, offer huge potential as functional ingredients.
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