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HDGF: a novel jack-of-all-trades in cancer

Cihang Bao1, Jianbo Wang, Wei Ma

  • 1Department of Radiation Oncology, Qilu Hospital of Shandong University, 107 Wenhua Road West, Jinan 250012, China.

Future Oncology (London, England)
|September 20, 2014
PubMed

Insights

Hepatoma-derived growth factor (HDGF) drives cancer progression, including transformation, angiogenesis, and metastasis. Understanding HDGF

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Hepatoma-derived growth factor (HDGF) is implicated in various cancer cell functions.
  • HDGF's diverse roles stem from its varied cellular localizations and interactions.
  • Elevated HDGF levels are observed in the serum of cancer patients.

Purpose of the Study:

  • To review the role of HDGF in tumorigenesis and metastasis.
  • To explore HDGF's potential as a clinical cancer therapy target.
  • To discuss HDGF's implications as a prognostic marker in cancer progression.

Main Methods:

  • Literature review of studies on HDGF.
  • Analysis of HDGF's molecular functions in cancer.
  • Examination of clinical data related to HDGF levels and patient outcomes.

Main Results:

  • HDGF significantly influences cancer cell transformation, apoptosis, angiogenesis, and metastasis.
  • HDGF interacts with multiple partners across different cellular compartments.
  • Serum HDGF levels correlate with certain cancer types.

Conclusions:

  • HDGF is a key regulator in cancer development and spread.
  • HDGF presents a promising target for novel cancer therapies.
  • HDGF holds potential as a valuable biomarker for cancer prognosis.
Keywords:
PWWP/HATH domainangiogenesisapoptosisepithelial-to-mesencyhmal transitionhepatoma-derived growth factormetastasismolecular mechanismsprognosisserum levelstumorigenesis

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