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Bipolar Disorder01:30

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Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
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Updated: Apr 23, 2026

Developing a Rat Model for Bipolar Disorder
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Understanding bipolar disorder: the epigenetic perspective.

Tarang Khare1, Mrinal Pal, Arturas Petronis

  • 1The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada, tarang_khare@camh.net.

Current Topics in Behavioral Neurosciences
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Summary

Bipolar disease (BPD) has a high heritability, but its genetic basis is unclear. Epigenetic factors, which modify DNA and chromatin, may play a significant role in BPD development and understanding them is key.

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Area of Science:

  • Psychiatry
  • Genetics
  • Epigenetics

Background:

  • Bipolar disease (BPD) affects 1-2% of the population with high heritability.
  • Genetic studies have yet to fully elucidate the cause of BPD.
  • Epigenetic factors are increasingly recognized as potential contributors to BPD.

Purpose of the Study:

  • To reanalyze epidemiological, clinical, and molecular findings in BPD.
  • To explore the role of inherited and acquired epigenetic misregulation in BPD.
  • To highlight the potential of epigenetic research in understanding BPD.

Main Methods:

  • Review of epidemiological data.
  • Analysis of clinical findings.
  • Reevaluation of molecular data through an epigenetic lens.

Main Results:

  • Epigenetic misregulation offers a new perspective on BPD etiology.
  • Stable yet reversible modifications of DNA and chromatin are implicated.
  • The complex nature of BPD may be better explained by epigenetic factors.

Conclusions:

  • Epigenetic research holds significant promise for advancing our understanding of BPD.
  • Investigating epigenetic mechanisms is crucial for future BPD research.
  • A comprehensive approach integrating genetics and epigenetics is needed for BPD.