Related Experiment Video
Updated: Apr 23, 2026
Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease
Published on: February 8, 2022
Super-resolution reconstruction of late gadolinium-enhanced MRI for improved myocardial scar assessment
Oleh Dzyubachyk1, Qian Tao1, Dirk H J Poot2
1Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Purpose:
To develop and validate a method for improving image resolution of late gadolinium-enhanced (LGE) magnetic resonance imaging (MRI) for accurate assessment of myocardial scar.
Materials And Methods:
In a cohort of 37 postinfarction patients, LGE was performed prior to ventricular tachycardia catheter ablation therapy at 1.5T. A super-resolution reconstruction (SRR) technique was applied to the three anisotropic views: short-axis (SA), two-chamber, and four-chamber, to reconstruct a single isotropic volume. For compensation of the interscan heart motion, a joint localized gradient-correlation-based scheme was developed. Scar was identified as either core or gray zone in both the SRR and original SA volumes, and evaluated based on the clinically established bipolar voltage range of the in vivo electroanatomical voltage mapping (EAVM).
Results:
Compared to the SA volume, the SRR method resulted in significantly (P < 0.05) reduced myocardial scar gray zone sizes (10.5 ± 8.8 g vs. 9.2 ± 8.1 g) and improved agreement of the bipolar voltage range of scar gray zone (0.99 ± 0.65 mV vs. 1.46 ± 1.15 mV).
Conclusion:
We propose an SRR method to automatically reconstruct a high-quality isotropic LGE volume from three orthogonal views. Analysis of the in vivo EAVM demonstrated improved myocardial scar assessment from the SRR volume compared with the SA LGE alone.
