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Updated: Apr 23, 2026

Author Spotlight: Advancements in Retroperitoneal Approach for Necrotizing Pancreatitis

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Published on: March 15, 2024

Spontaneous retroperitoneal bleeding: a case series.

Hitoshi Yamamura¹, Takasei Morioka, Tomonori Yamamoto

¹Department of Critical Care Medicine, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abenoku, Osaka 545-8585, Japan. yamamura@med.osaka-cu.ac.jp.

BMC Research Notes

|September 20, 2014

Summary

This summary is machine-generated.

Spontaneous retroperitoneal bleeding is a rare condition. Anticoagulant therapy, particularly with nafamostat mesilate, may increase the risk in patients with progressive anemia and unstable vital signs.

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Area of Science:

Nephrology
Vascular Surgery
Internal Medicine

Background:

Spontaneous retroperitoneal bleeding is a rare but serious condition.
Four Japanese patients with this condition were analyzed.
The study aimed to characterize clinical features and identify risk factors.

Purpose of the Study:

To categorize clinical characteristics of spontaneous retroperitoneal bleeding.
To discuss potential risk factors for this rare disease.

Main Methods:

Retrospective case series of four patients.
Analysis of clinical data, laboratory results, and causative vessels.
Review of anticoagulant and renal replacement therapy.
Hemostasis achieved via transcatheter arterial embolization or surgery.

Main Results:

Three patients lacked pre-existing bleeding tendencies based on laboratory data.
Affected arteries included lumbar, superior gluteal, and internal iliac arteries.
All patients received anticoagulants (heparin or nafamostat mesilate).
Three patients were undergoing renal replacement therapy (hemodialysis or continuous hemodiafiltration).

Conclusions:

Spontaneous retroperitoneal bleeding should be suspected in patients on anticoagulants with anemia and unstable vitals.
Nafamostat mesilate may be a significant risk factor for spontaneous retroperitoneal bleeding.