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Catalytic hydroamination of unactivated olefins using a Co catalyst for complex molecule synthesis
Hiroki Shigehisa1, Natsumi Koseki, Nao Shimizu
1Faculty of Pharmacy, Musashino University , 1-1-20 Shinmachi Nishitokyo-shi, Tokyo 202-8585, Japan.
Abstract:
Functional group tolerance is one of the important requirements for chemical reactions, especially for the synthesis of complex molecules. Herein, we report a mild, general, and functional group tolerant intramolecular hydroamination of unactivated olefins using a Co(salen) complex, an N-fluoropyridinium salt, and a disiloxane reagent. This method, which was carried out at room temperature (or 0 °C), afforded three-, five-, six-, and seven-membered ring nitrogen-containing heterocyclic compounds and was compatible with diverse functional groups.
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