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Nontraditional serum lipid variables and recurrent stroke risk

Jong-Ho Park1, Juneyoung Lee1, Bruce Ovbiagele1

  • 1From the Department of Stroke Neurology, Myongji Hospital, Goyang, Korea (J.-H.P.); Department of Biostatistics, College of Medicine, Korea University, Seoul, Korea (J.L.); and Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina (J.-H.P., B.O.).

Stroke
|September 20, 2014
PubMed

Insights

The triglycerides/high-density lipoprotein cholesterol (HDL-C) ratio, not LDL-C, predicts recurrent stroke and vascular events. This lipid ratio may be a therapeutic target for stroke survivors.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Lipidology

Background:

  • Current stroke guidelines prioritize low-density lipoprotein cholesterol (LDL-C) for secondary prevention.
  • Emerging evidence suggests other lipid parameters may also predict cardiovascular risk.
  • The impact of nontraditional lipid variables on recurrent stroke risk remains under-investigated.

Purpose of the Study:

  • To investigate the association of nontraditional lipid variables with recurrent ischemic stroke risk.
  • To evaluate the predictive value of various lipid ratios and components for vascular events post-stroke.

Main Methods:

  • Analysis of the Vitamin Intervention for Stroke Prevention study database (n=3680).
  • Inclusion of recent noncardioembolic stroke patients with 2-year follow-up.
  • Assessment of independent associations between baseline lipid variables and outcomes.

Main Results:

  • Elevated triglycerides/high-density lipoprotein cholesterol (HDL-C) ratio independently predicted recurrent ischemic stroke and composite vascular events.
  • The highest quintile of triglycerides/HDL-C ratio showed increased risk for stroke (aHR, 1.56) and composite events (aHR, 1.39).
  • Elevated total cholesterol/HDL-C ratio predicted composite vascular events, but not recurrent stroke independently.

Conclusions:

  • The triglycerides/HDL-C ratio is a significant predictor of vascular risk after stroke.
  • This lipid ratio, unlike LDL-C, may serve as a potential therapeutic target for reducing global vascular risk in stroke patients.
  • Further research is warranted to confirm the therapeutic role of targeting the triglycerides/HDL-C ratio.
Abstract

Keywords:
cardiovascular diseaseslipidsstroke

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