Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Allele Traits01:49

Multiple Allele Traits

32.4K
The Concept of Multiple Allelism
32.4K
Dihybrid Crosses01:18

Dihybrid Crosses

61.2K
Overview
61.2K
X-linked Traits01:19

X-linked Traits

45.4K
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
45.4K
X-linked Traits01:19

X-linked Traits

6.3K
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating genetic overlap of multidimensional pain and suicidal behaviors in >2 million individuals.

Research square·2026
Same author

Identification of novel candidate neural genes for diet-induced obesity in outbred heterogeneous stock rats.

Research square·2026
Same author

Data-driven prioritization of mouse strains for improved preclinical modeling of rare and common disease.

bioRxiv : the preprint server for biology·2026
Same author

Comparison of Deep Learning Tools for Optic Nerve Axon Quantification Finds Limited Generalizability on Independent Validation.

bioRxiv : the preprint server for biology·2026
Same author

NBL1 associates with renal phenotypes in mice, but partial Nbl1 reduction does not ameliorate kidney disease.

American journal of physiology. Renal physiology·2026
Same author

Simplifying Systems Genetics with QTLretrievR: An R Package for Molecular QTL Identification.

bioRxiv : the preprint server for biology·2026
Same journal

Duplication-based genetic dissection of the Down syndrome critical region reveals its complex functional organization.

G3 (Bethesda, Md.)·2026
Same journal

The complete sequence of the silkworm W chromosome uncovers its rapid evolution by large-scale duplications/deletions and translocation of W-linked genes.

G3 (Bethesda, Md.)·2026
Same journal

Revisiting the genome assembly of Lupinus species reveals differential diploidization after a shared whole-genome duplication.

G3 (Bethesda, Md.)·2026
Same journal

Deconstructing empirical fitness seascapes across scales of granularity.

G3 (Bethesda, Md.)·2026
Same journal

Genomes of Conopholis americana and Epifagus virginiana: Two holoparasitic plants (Orobanchaceae).

G3 (Bethesda, Md.)·2026
Same journal

"A chromosome-level reference genome for the colonial marine hydrozoan Podocoryna americana".

G3 (Bethesda, Md.)·2026
See all related articles

Related Experiment Video

Updated: Apr 23, 2026

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
10:08

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

13.6K

Quantitative trait locus mapping methods for diversity outbred mice.

Daniel M Gatti1, Karen L Svenson1, Andrey Shabalin2

  • 1The Jackson Laboratory, Bar Harbor, Maine 04609.

G3 (Bethesda, Md.)
|September 20, 2014
PubMed
Summary
This summary is machine-generated.

Genetic mapping in Diversity Outbred (DO) mice offers enhanced resolution for complex traits. This study presents an analytical pipeline and R package (DOQTL) to leverage multiparental outbreeding for gene discovery.

Keywords:
MPPMultiparent Advanced Generation Inter-Cross (MAGIC)Multiparental populationsdiversity outbredhaplotype reconstructionquantitative trait locus mapping

More Related Videos

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR
06:18

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR

Published on: July 11, 2025

918
Measuring Active and Passive Tameness Separately in Mice
07:13

Measuring Active and Passive Tameness Separately in Mice

Published on: August 10, 2018

6.6K

Related Experiment Videos

Last Updated: Apr 23, 2026

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
10:08

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

13.6K
Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR
06:18

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR

Published on: July 11, 2025

918
Measuring Active and Passive Tameness Separately in Mice
07:13

Measuring Active and Passive Tameness Separately in Mice

Published on: August 10, 2018

6.6K

Area of Science:

  • Genetics
  • Genomics
  • Quantitative Trait Loci (QTL) analysis

Background:

  • Traditional genetic mapping using single-generation crosses has limitations in resolution and scope.
  • Multiparent outbreeding populations, like the Diversity Outbred (DO) mice, increase recombination density and allelic diversity.
  • Analyzing multiparent crosses requires specialized methods to handle unique genotypes and complex relatedness.

Purpose of the Study:

  • To develop and present a comprehensive analytical pipeline for genetic mapping in the Diversity Outbred mouse population.
  • To enable efficient identification of genes underlying complex phenotypes using multiparental outbreeding data.
  • To provide accessible tools for the research community through an R package.

Main Methods:

  • Probabilistic reconstruction of founder haplotypes from genotyping array intensity data.
  • Development of mapping methods accommodating multiple founder haplotypes and accounting for polygenic covariance.
  • Implementation of the analytical pipeline in the freely available R package DOQTL.

Main Results:

  • The analytical pipeline successfully reconstructs founder haplotypes and performs genetic mapping in the DO population.
  • Power analysis indicates that as few as 200 DO mice can detect large-effect loci.
  • Detecting loci with smaller effects (<5% trait variance) may require up to 1000 animals.

Conclusions:

  • The presented analytical pipeline and DOQTL package provide a robust framework for genetic mapping in the Diversity Outbred mouse population.
  • This approach significantly enhances the ability to discover genes for complex traits by leveraging increased genetic diversity and recombination.
  • The freely available tools facilitate broader application of advanced genetic mapping strategies in model organisms.