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The effect on motion sickness and oculomotor function of GR 38032F, a 5-HT3-receptor antagonist with anti-emetic

J R Stott1, G R Barnes, R J Wright

  • 1R.A.F. Institute of Aviation Medicine, Farnborough, Hampshire.

British Journal of Clinical Pharmacology
|February 1, 1989
PubMed

Insights

The 5-HT3 receptor antagonist GR 38032F did not prevent motion sickness, unlike hyoscine. This indicates distinct neural pathways for motion sickness and chemotherapy-induced vomiting.

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • The 5-hydroxytryptamine (5-HT3) receptor antagonist GR 38032F is effective against chemotherapy-induced vomiting.
  • Motion sickness and chemotherapy-induced vomiting may involve different neural mechanisms.

Purpose of the Study:

  • To evaluate the efficacy of GR 38032F in preventing motion sickness.
  • To compare GR 38032F with hyoscine and placebo for motion sickness prophylaxis.
  • To investigate the effects of GR 38032F and hyoscine on oculomotor function.

Main Methods:

  • A double-blind trial comparing GR 38032F, placebo (lactose), and hyoscine.
  • Administration of drugs to induce motion sickness via cross-coupled stimulation.
  • Assessment of ocular pursuit and saccadic eye movements.

Main Results:

  • GR 38032F showed no prophylactic effect against motion-induced nausea, similar to placebo.
  • Hyoscine significantly increased tolerance to motion sickness (P < 0.001).
  • Neither drug affected saccadic eye movements, but both reduced pursuit eye movement velocity gain (P < 0.05).

Conclusions:

  • The 5-HT3 receptor is likely not involved in motion sickness pathways.
  • The 5-HT3 receptor may play a role in regulating ocular pursuit.
  • Motion sickness and chemotherapy-induced vomiting involve different underlying neural mechanisms.

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