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Related Experiment Video

Updated: Apr 23, 2026

Novel Sequence Discovery by Subtractive Genomics

Novel Sequence Discovery by Subtractive Genomics

Published on: January 25, 2019

Sequence Bundles: a novel method for visualising, discovering and exploring sequence motifs.

Marek Kultys¹, Lydia Nicholas¹, Roland Schwarz²

¹Science Practice Ltd, London, 83-85 Paul Street, EC2A 4NQ, UK.

BMC Proceedings

|September 20, 2014

Summary

Sequence Bundles is a new bioinformatics visualization method for multiple sequence alignments (MSAs). It reveals hidden sequence motifs and conservation patterns, offering insights beyond traditional tools like Sequence Logos.

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Area of Science:

Bioinformatics
Computational Biology
Data Visualization

Background:

Existing bioinformatics visualization methods, such as Sequence Logos, have limitations in representing complex data.
Novel data visualization methods are needed to address these limitations and reveal hidden patterns in biological data.

Purpose of the Study:

Introduce Sequence Bundles, a novel visualization method for multiple sequence alignments (MSAs).
Enable salient visual expression of sequence motifs and other data features.
Address limitations of existing bioinformatics visualization methods.

Main Methods:

Developed Sequence Bundles using research-led information design methodologies.
Encoded sequences as uninterrupted, semi-opaque lines on a 2D reconfigurable grid.
Utilized line thickness, opacity, and curved paths to represent conservation, correlation, and functionality.

Main Results:

Developed a software application for generating Sequence Bundles visualizations.
Discovered interesting features in MSAs, including extreme sequence conservation and consensus sequence bifurcations.
Demonstrated the ability to visualize multiple MSAs in a composite image.

Conclusions:

Sequence Bundles is a novel method for MSA visualization and sequence motif discovery.
Aids in generating new insights and hypotheses.
Well-suited for future interactive visual analytics software development.