The effect of topical 1% cyclopentolate on IOLMaster biometry

Area of Science:

• Ophthalmology
• Biometry
• Pharmacology

Background:

• Ocular biometry is crucial for refractive error assessment and intraocular lens calculation.
• Cyclopentolate is a commonly used anticholinergic mydriatic agent.
• Understanding its impact on ocular measurements is vital for accurate clinical interpretation.

Purpose of the Study:

• To evaluate the effect of topical 1% cyclopentolate on key ocular biometry parameters.
• To assess changes in anterior chamber depth, iris width, and axial length.
• To determine the clinical relevance for measurements obtained with the IOLMaster device.

Main Methods:

• Prospective study involving healthy young adults.
• Ocular biometry performed using the IOLMaster device at two intervals.
• Comparison between eyes treated with 1% cyclopentolate and a control group.

Main Results:

• Topical cyclopentolate significantly increased anterior chamber depth (p<0.05).
• Horizontal iris width (white-to-white distance) also showed a significant increase (p<0.05).
• No significant alteration in axial length was observed post-cyclopentolate application.

Conclusions:

• Topical 1% cyclopentolate induces measurable changes in anterior chamber depth and white-to-white distance.
• These induced changes do not affect axial length measurements.
• Clinicians should consider cyclopentolate-induced biometric alterations when interpreting IOLMaster data in young adults.