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Rhinocerebral mucormycosis: Pathology revisited with emphasis on perineural spread

Tumuluri Sravani, Shantveer Gurulingappa Uppin, Megha Shantveer Uppin

  • 1Department of Pathology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Andhra Pradesh, India.

Neurology India
|September 20, 2014
PubMed
Abstract

Insights

Perineural invasion is a key histopathological feature in invasive rhinocerebral mucormycosis. This finding indicates a more advanced stage of the fungal infection and its spread within tissues.

Area of Science:

  • Pathology
  • Mycology
  • Infectious Diseases

Background:

  • Invasive rhinocerebral mucormycosis is a severe fungal infection.
  • Histopathological features are crucial for diagnosis and understanding disease progression.

Purpose of the Study:

  • To investigate the histopathological characteristics of invasive rhinocerebral mucormycosis.
  • To specifically focus on the significance of perineural invasion in this condition.

Main Methods:

  • Histopathological examination of 30 patient tissue samples using Hematoxylin and Eosin (H&E), Gomori's Methenamine Silver (GMS), and Periodic Acid Schiff (PAS) stains.
  • Evaluation of inflammation, soft tissue invasion, angioinvasion, and perineural spread.
  • Correlation with demographic, clinical, and predisposing factors.

Main Results:

  • Perineural invasion was identified in 15 out of 19 biopsies where peripheral nerves were present.
  • Angioinvasion was observed in 25 biopsies, and soft tissue invasion in 20.
  • Suppurative inflammation predominated, and infarction/necrosis was common.

Conclusions:

  • Perineural invasion is a significant histopathological finding in invasive rhinocerebral mucormycosis.
  • Its presence suggests an advanced stage and extensive spread of the infection.

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