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Updated: Apr 23, 2026

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
Published on: October 25, 2011
Specialization and bet hedging in heterogeneous populations
Steffen Rulands1, David Jahn1, Erwin Frey1
1Department of Physics, Arnold-Sommerfeld-Center for Theoretical Physics and Center for NanoScience, Ludwig-Maximilians-Universität München, Theresienstrasse 37, D-80333 Munich, Germany.
Abstract:
Phenotypic heterogeneity is a strategy commonly used by bacteria to rapidly adapt to changing environmental conditions. Here, we study the interplay between phenotypic heterogeneity and genetic diversity in spatially extended populations. By analyzing the spatiotemporal dynamics, we show that the level of mobility and the type of competition qualitatively influence the persistence of phenotypic heterogeneity. While direct competition generally promotes persistence of phenotypic heterogeneity, specialization dominates in models with indirect competition irrespective of the degree of mobility.
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