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Updated: Apr 23, 2026
Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
Published on: March 29, 2019
[Neuroendocrine carcinoma of the urinary bladder. A case report]
Anel Rogelio Aragón-Tovar1, Marco Elí Pineda-Rodríguez2, Francisco Edgardo Puente-Gallegos3
1Servicio de Urología, Unidad Médica de Alta Especialidad 25, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, México. dr_anel_aragon@terra.com.mx.
Background:
Small cell carcinoma of the urinary bladder is an infrequent lesion.
Clinical Case:
We present the case of a 68-year-old male who arrived at the emergency room with a history of 24-h gross hematuria. Imaging studies show a urinary bladder tumor with a 218 cc volume that during a 20-day period increased to 426 cc. Histopathological images with hematoxylin-eosin show an infiltrating solid mass with uneven borders. It is composed of neoplastic cells with evident nuclei predominance and scant cytoplasm (small cells). Chromogranin immunohistochemical staining shows a diffusely positive cytoplasmic granular pattern on neoplastic cells. High molecular weight cytokeratin staining shows a negative pattern on neoplastic cells along with a positive pattern on reporsurrounding normal urothelium. Tumoral mass is positive for synaptophysin and CD-56 and negative for CK-7 and CK-20. Patient therapy was based on radiation plus chemotherapy.
Conclusion:
Small cell carcinoma of the urinary bladder represents 0.35-0.70% of urinary bladder tumors. Histological and immunohistochemical identification are key elements in the diagnosis. Treatment approach is based on cisplatin-based chemotherapy plus radical cystectomy, except when metastatic disease is present.
