α-Tocopheryl Phosphate as a Bioactive Derivative of Vitamin E: A Review of the Literature

α-Tocopheryl phosphate (α-TP) is a naturally occurring derivative of α-tocopherol (α-T), one of the eight isoforms of vitamin E. α-TP is present at very low intracellular concentrations, traffics across plasma membranes, and affects many important cellular functions. In addition to being a signaling molecule, α-TP has also been shown to possess antioxidant and potentially antiatherosclerotic properties that are more potent than its parent compound (α-T). However, there is little published data on the clinical effects of α-TP supplements, the mechanisms involved in its metabolism and cellular function, and reliable methods for its determination in plasma.