Related Experiment Video
Updated: Apr 23, 2026
Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
Published on: October 2, 2020
The relationship between the level of serum 25-hydroxyvitamin D and renal function in patients without chronic kidney
Young Jin Tak1, Jeong Gyu Lee1, Sang Heon Song2
1Department of Family Medicine, Pusan National University School of Medicine, Busan, Republic of Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Objectives:
Low level of vitamin D has been suggested as a risk factor for chronic kidney disease (CKD). However, little is known about the effect of vitamin D on renal function in healthy subjects. Our aim was to investigate the question of whether vitamin D status is associated with renal function in subjects without CKD.
Methods:
In this cross-sectional study, 1,648 subjects aged older than 20 years were recruited as study participants. Subjects diagnosed with either CKD or other conditions that could influence serum vitamin D were excluded. Estimated glomerular filtration rate (eGFR) from serum creatinine (sCr) was used for the determination of renal function. Vitamin D status was determined by the measurement of serum 25-hydroxyvitamin D [25(OH)D] levels.
Results:
In men, 25(OH)D showed significant positive correlation with age (r = 0.127, P < .001), skeletal muscle mass (r = 0.077, P = .017), sCr (r = 0.128, P < .001), and negative correlation with body fat (r = -0.065, P = .044), eGFR (r = -0.152, P < .001). In women, 25(OH)D showed negative correlation with eGFR (r = -0.085, P = .026), but not with age and body composition. In multiple linear regression analysis, 25(OH)D (β = 0.114, P < .001), total muscle mass (β = 0.202, P = .026), and age (β = 0.117, P = .003) were an independent determinant of sCr in men; in women, 25(OH)D (β = 0.086, P = .023), total muscle mass (β = 0.152, P < .001) were variables showing significant association with sCr.
Conclusions:
Higher level of 25(OH)D is independently associated with sCr elevation. We suggest that a positive correlation between 25(OH)D and muscle mass could be attributed to sCr. It is thought to be another mechanism of serum 25(OH)D level in renal function in populations without CKD.
