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Progress towards the integration of pharmacogenomics in practice
1Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA, smooney@buckinstitute.org.
Human Genetics
|September 21, 2014
Summary
Pharmacogenomics uses genetic information to personalize drug treatments, but clinical application faces challenges. Ongoing research aims to overcome these hurdles for widespread patient benefit.
Area of Science:
- Genetics and Pharmacology
- Clinical Research
Background:
- Pharmacogenomics research aims to link genetic variants to drug response for clinical use.
- Discoveries are curated into resources for researchers and clinicians.
Purpose of the Study:
- To review pharmacogenomic variants, resources, and clinical guidelines.
- To discuss challenges and the impact of pharmacogenomics on drug development and regulatory approval.
Main Methods:
- Review of current literature on pharmacogenomics.
- Analysis of emerging technologies like PheWAS and whole genome sequencing (WGS).
Main Results:
- Pharmacogenomic variants are distinct from disease variants and polymorphisms.
- Significant challenges remain for widespread clinical implementation.
Conclusions:
- Clinical guidelines for pharmacogenomic testing are nascent.
- Rapidly evolving sequencing technologies and data return policies present ongoing debates.
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