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Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
An immunology primer for computational modelers
William F Hawse1, Penelope A Morel
1Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA, whawse@pitt.edu.
Abstract:
The immune system is designed to protect an organism from infection and damage caused by a pathogen. A successful immune response requires the coordinated function of multiple cell types and molecules in the innate and adaptive immune systems. Given the complexity of the immune system, it would be advantageous to build computational models to better understand immune responses and develop models to better guide the design of immunotherapies. Often, researchers with strong quantitative backgrounds do not have formal training in immunology. Therefore, the goal of this review article is to provide a brief primer on cellular immunology that is geared for computational modelers.
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