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Is physical behavior affected in fatigued persons with multiple sclerosis?

Lyan J Blikman1, Jetty van Meeteren1, Herwin L Horemans1

  • 1Department of Rehabilitation Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Archives of Physical Medicine and Rehabilitation
|September 21, 2014
PubMed
Summary

Fatigued individuals with multiple sclerosis (MS) exhibit significantly reduced physical activity and altered daily movement patterns compared to healthy controls. This study highlights differences in activity levels, intensity, and distribution throughout the day.

Keywords:
Motor activityMultiple sclerosisRehabilitationSedentary lifestyle

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Area of Science:

  • Neurology
  • Rehabilitation Science
  • Human Movement Science

Background:

  • Fatigue is a prevalent and debilitating symptom in multiple sclerosis (MS).
  • Understanding the detailed physical behavior of fatigued individuals with MS is crucial for targeted interventions.

Purpose of the Study:

  • To comprehensively analyze the physical behavior of fatigued individuals with MS using objective measurements.
  • To compare the physical activity patterns, intensity, and distribution between fatigued MS patients and healthy controls.

Main Methods:

  • A case-control explorative study design was employed.
  • Twenty-three ambulatory, fatigued individuals with MS were matched with 23 healthy, non-fatigued controls.
  • Objective physical behavior data were collected over 7 days using accelerometers, measuring activity levels, intensity, and daily distribution.

Main Results:

  • Individuals with MS demonstrated significantly lower overall physical activity (counts per day, counts per minute) compared to controls.
  • MS participants exhibited a higher percentage of sedentary time and less time spent in moderate-to-vigorous physical activity (MVPA).
  • Distinct differences were observed in the daily distribution of sedentary and MVPA periods between the MS and control groups.

Conclusions:

  • Ambulatory individuals with MS experiencing fatigue display significant deviations in physical behavior beyond just activity levels.
  • These differences encompass daily patterns, activity intensity, and the distribution of movement throughout the day.
  • Findings underscore the need for interventions addressing the multifaceted nature of physical behavior impairments in fatigued MS patients.