Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Calibration of MRI-based reference intervals to new samples.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

ComBat-Predict Enhances Generalizability of Neuroimaging Models to New Sites.

Human brain mapping·2026
Same author

Impact of Fluoxetine Brain Concentrations, Plasma Exposure, and Neurometabolism on Depressive and Anxiety Symptoms in Adolescents: A Multimodal Fluorine and Proton Magnetic Resonance Spectroscopy Study.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

Monte Carlo Assessment of Accuracy for Mean Kärger Model Water Exchange Rate Estimates From Diffusional Kurtosis Time Dependence.

NMR in biomedicine·2026
Same author

Central Nervous System Iron Content in Pediatric CKD.

Kidney international reports·2025
Same author

Calibration of MRI-based reference intervals to new samples.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Apr 23, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

25.9K

Human brain asymmetry in microstructural connectivity demonstrated by diffusional kurtosis imaging.

Chu-Yu Lee1, Ali Tabesh1, Travis Nesland2

  • 1Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA; Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, USA.

Brain Research
|September 21, 2014
PubMed
Summary

Diffusional kurtosis imaging (DKI) tractography reveals more brain white matter (WM) structural asymmetries than diffusion tensor imaging (DTI). This advanced method enhances understanding of brain connectivity and functional lateralization.

Keywords:
ConnectivityConnectomeDiffusion tensor imagingDiffusional kurtosis imagingMRIStructural asymmetry

More Related Videos

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

24.5K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

27.9K

Related Experiment Videos

Last Updated: Apr 23, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

25.9K
Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

24.5K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

27.9K

Area of Science:

  • Neuroimaging
  • Neuroanatomy
  • Brain Connectomics

Background:

  • Structural asymmetry in brain white matter (WM) pathways, the connectome, is known via diffusion tensor imaging (DTI) tractography.
  • DTI tractography has limitations in resolving intersecting axonal fibers within voxels, potentially underestimating asymmetry.

Purpose of the Study:

  • To assess brain structural asymmetry using diffusional kurtosis imaging (DKI) tractography.
  • To compare DKI-based tractography with DTI-based methods for identifying asymmetries in WM pathways.

Main Methods:

  • Acquired DKI images from 42 healthy subjects.
  • Parcellated gray matter (GM) into regions of interest (ROIs) using automatic segmentation.
  • Reconstructed WM pathways and quantified connectivity using both DKI and DTI tractography.
  • Calculated asymmetry index (AI) for ROIs and inter-ROI connections.

Main Results:

  • DKI tractography identified widespread leftward and rightward asymmetrical ROIs and connections across various brain lobes and structures.
  • Observed structural asymmetries were incompletely detected using DTI-based tractography.
  • Significant asymmetries were noted in frontal, parietal, temporal lobes, insula, cingulate cortex, and basal ganglia.

Conclusions:

  • DKI-based tractography offers improved identification of asymmetrical brain connectivity patterns compared to DTI.
  • DKI serves as a valuable tool for evaluating the structural underpinnings of functional lateralization.
  • This study highlights the potential of DKI in advancing connectome asymmetry research.