Importance of risk factor management in diabetic patients and reduction in Stage B heart failure

G Murtagh1, J O Connell2, E O Connell1

  • 1From the The Chronic Cardiovascular Disease Management Unit, St Vincent's University Hospital Health Care Group, Elm Park, Dublin 4, Ireland, Department of Endocrinology, St Vincent's University Hospital Health Care Group, Elm Park, Dublin 4, Ireland and School of Medicine and Medical Sciences, University College Dublin, Belfield, Dublin 4, Ireland.

Insights

Diabetes increases heart failure risk, but good risk factor control in diabetic patients may prevent diabetic cardiomyopathy. Effective management is key for cardiovascular outcomes.

Area of Science:

  • Cardiology
  • Diabetology
  • Heart Failure Research

Background:

  • Diabetic cardiomyopathy is a known complication, increasing heart failure risk in diabetic patients.
  • Contemporary risk factor control may influence the prevalence of diabetes-associated cardiomyopathy.

Purpose of the Study:

  • To assess the current impact of diabetes mellitus on cardiomyopathy prevalence.
  • To evaluate this impact with and without adjusting for risk factor control in at-risk patients.

Main Methods:

  • Cross-sectional study of patients at risk for heart failure (St Vincent's Screening to Prevent Heart Failure cohort).
  • Comparison of diabetic patients with those having other cardiovascular risk factors, with multiple matching criteria (age, gender, BMI, blood pressure, LDL cholesterol).

Main Results:

  • No significant difference in Stage B heart failure (asymptomatic cardiomyopathy) between diabetic and non-diabetic patients when matched for age and gender.
  • Stage B heart failure was more prevalent in diabetic patients (22.2%) compared to non-diabetic patients (16.4%) after controlling for risk factors (P=0.048).

Conclusions:

  • Effective risk factor management in diabetic patients appears to mitigate the direct negative impact of diabetes on left ventricular structure and function.
  • Highlights the critical importance of robust risk factor control for improving cardiovascular outcomes in diabetic individuals at risk for heart failure.
Abstract

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