Related Experiment Video
Updated: Apr 23, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Importance of risk factor management in diabetic patients and reduction in Stage B heart failure
G Murtagh1, J O Connell2, E O Connell1
1From the The Chronic Cardiovascular Disease Management Unit, St Vincent's University Hospital Health Care Group, Elm Park, Dublin 4, Ireland, Department of Endocrinology, St Vincent's University Hospital Health Care Group, Elm Park, Dublin 4, Ireland and School of Medicine and Medical Sciences, University College Dublin, Belfield, Dublin 4, Ireland.
Insights
Diabetes increases heart failure risk, but good risk factor control in diabetic patients may prevent diabetic cardiomyopathy. Effective management is key for cardiovascular outcomes.
Area of Science:
- Cardiology
- Diabetology
- Heart Failure Research
Background:
- Diabetic cardiomyopathy is a known complication, increasing heart failure risk in diabetic patients.
- Contemporary risk factor control may influence the prevalence of diabetes-associated cardiomyopathy.
Purpose of the Study:
- To assess the current impact of diabetes mellitus on cardiomyopathy prevalence.
- To evaluate this impact with and without adjusting for risk factor control in at-risk patients.
Main Methods:
- Cross-sectional study of patients at risk for heart failure (St Vincent's Screening to Prevent Heart Failure cohort).
- Comparison of diabetic patients with those having other cardiovascular risk factors, with multiple matching criteria (age, gender, BMI, blood pressure, LDL cholesterol).
Main Results:
- No significant difference in Stage B heart failure (asymptomatic cardiomyopathy) between diabetic and non-diabetic patients when matched for age and gender.
- Stage B heart failure was more prevalent in diabetic patients (22.2%) compared to non-diabetic patients (16.4%) after controlling for risk factors (P=0.048).
Conclusions:
- Effective risk factor management in diabetic patients appears to mitigate the direct negative impact of diabetes on left ventricular structure and function.
- Highlights the critical importance of robust risk factor control for improving cardiovascular outcomes in diabetic individuals at risk for heart failure.
Background:
A number of studies have demonstrated the presence of a diabetic cardiomyopathy, increasing the risk of heart failure development in this population. Improvements in present-day risk factor control may have modified the risk of diabetes-associated cardiomyopathy.
Aim:
We sought to determine the contemporary impact of diabetes mellitus (DM) on the prevalence of cardiomyopathy in at-risk patients with and without adjustment for risk factor control.
Design:
A cross-sectional study in a population at risk for heart failure.
Methods:
Those with diabetes were compared to those with other cardiovascular risk factors, unmatched, matched for age and gender and then matched for age, gender, body mass index, systolic blood pressure and low density lipoprotein cholesterol.
Results:
In total, 1399 patients enrolled in the St Vincent's Screening to Prevent Heart Failure (STOP-HF) cohort were included. About 543 participants had an established history of DM. In the whole sample, Stage B heart failure (asymptomatic cardiomyopathy) was not found more frequently among the diabetic cohort compared to those without diabetes [113 (20.8%) vs. 154 (18.0%), P = 0.22], even when matched for age and gender. When controlling for these risk factors and risk factor control Stage B was found to be more prevalent in those with diabetes [88 (22.2%)] compared to those without diabetes [65 (16.4%), P = 0.048].
Conclusion:
In this cohort of patients with established risk factors for Stage B heart failure superior risk factor management among the diabetic population appears to dilute the independent diabetic insult to left ventricular structure and function, underlining the importance and benefit of effective risk factor control in this population on cardiovascular outcomes.
Related Concept Videos
Heart Failure V: Medical Management
Heart Failure IV: Classification and Diagnostic Evaluation
Atherosclerosis III: Management
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Heart Failure Drugs: β-Blockers
Heart Failure VII: Nursing Interventions

