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Simultaneous two-probe laser Doppler velocimetric assessment of topically applied drugs in rats
G M Hirkaler1, L B Rosenberger
1Department of Pharmacology, Hoffmann-La Roche Inc., Nutley, New Jersey.
Journal of Pharmacological Methods
|April 1, 1989
Abstract:
A simple, noninvasive method for the determination of cutaneous blood flow in anesthetized rats is presented. Simultaneous two-probe laser doppler velocimetry is shown to be a useful preclinical tool for the assessment of topically applied drugs.