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Updated: Apr 23, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Complex and mixture of β-cyclodextrin with diazepam characterised by ¹H NMR and atom-atom potential methods
A Pajzderska1, J Mielcarek2, J Wąsicki1
1Faculty of Physics, A. Mickiewicz University, Umultowska 85, 61-614 Poznan, Poland.
Abstract:
Inclusion complex of β-cyclodextrin with diazepam and a physical mixture of these components were studied by solid-state (1)H NMR. The activation barrier for reorientation of the methyl group in the diazepam molecule was found not changed by complex formation with β-cyclodextrin. The complex formation resulted in a decrease in the number of water molecules and affected the relaxation time of β-cyclodextrin. By the atom-atom potential method the most probable configuration of the diazepam molecule inside β-cyclodextrin cavity was proposed.
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