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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Clinical aspects of malt lymphomas
Christina Kalpadakis1, Gerassimos A Pangalis, Theodoros P Vassilakopoulos
1Department of Haematology, Heraklion University Hospital, University of Crete, POBOX 1352, Heraklion, Crete, Greece, xkalpadaki@yahoo.gr.
Current Hematologic Malignancy Reports
|September 22, 2014
Summary
Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT) is a slow-growing cancer. Stomach MALT lymphoma is strongly linked to Helicobacter pylori infection, with good survival rates for most patients.
Area of Science:
- Oncology
- Pathology
- Immunology
Background:
- Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT) is an indolent lymphoma originating outside lymph nodes.
- Infectious agents and autoimmune disorders are implicated in MALT lymphoma pathogenesis.
- The stomach is the most common site for MALT lymphoma, with a strong association with Helicobacter pylori (Hp) infection.
Purpose of the Study:
- To review the current understanding of MALT lymphoma etiology.
- To discuss the cellular and molecular pathological events in MALT lymphoma development.
- To highlight advancements in clinical understanding and treatment strategies for MALT lymphomas.
Main Methods:
- Literature review of MALT lymphoma research.
- Analysis of etiological factors, including infectious agents like Hp.
- Examination of cellular and molecular pathology.
Main Results:
- MALT lymphomas typically follow an indolent clinical course.
- Most patients experience excellent survival, often irrespective of treatment.
- Strong etiological link between Hp infection and gastric MALT lymphoma established.
Conclusions:
- Advances in understanding MALT lymphoma's origins and mechanisms have improved clinical insights.
- Improved knowledge facilitates better definition of treatment strategies for MALT lymphomas.
- Gastric MALT lymphoma management is significantly influenced by Hp status.
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