Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

25
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
25
Mismatch Repair01:20

Mismatch Repair

5.4K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Socioeconomic inequality in treatment of acute myeloid leukaemia (AML) in England, 2015-2022: A population-based study.

British journal of haematology·2026
Same author

Reattempt of tyrosine kinase inhibitor discontinuation after maintenance therapy with ponatinib in patients with chronic myeloid leukaemia in the chronic phase: Result of the Japan Adult Leukemia Study Group RE-STOP219 study.

British journal of haematology·2026
Same author

Real-world, multi-omics validation of the clinical relevance of molecular taxonomy for myelodysplastic syndromes (MDS).

HemaSphere·2026
Same author

Treatment-Free Remission and Immune Profiling after Frontline Second-Generation TKI Therapy in CML.

Blood advances·2026
Same author

Clinical Outcomes and Exploratory Longitudinal CTL/Vβ Repertoire Remodeling in Patients with Relapsed or Refractory Large B-Cell Lymphoma and Follicular Lymphoma Treated with Epcoritamab.

International journal of molecular sciences·2026
Same author

Early predictors of MR4.5 attainment and eligibility for TKI discontinuation in CML treated with second-generation TKIs.

Blood advances·2026

Related Experiment Video

Updated: Apr 23, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

9.0K

Lessons from the atomic bomb about secondary MDS.

Tomoko Hata1, Daisuke Imanishi, Yasushi Miyazaki

  • 1Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki, 852-8523, Japan.

Current Hematologic Malignancy Reports
|September 22, 2014
PubMed
Summary

Exposure to external radiation significantly increases myelodysplastic syndromes (MDS) risk. This review compares secondary MDS and leukemia/MDS in atomic bomb survivors to identify risk factors.

More Related Videos

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
07:08

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis

Published on: August 31, 2022

1.6K
Dual Immunofluorescence of γH2AX and 53BP1 in Human Peripheral Lymphocytes
05:34

Dual Immunofluorescence of γH2AX and 53BP1 in Human Peripheral Lymphocytes

Published on: July 14, 2023

2.7K

Related Experiment Videos

Last Updated: Apr 23, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

9.0K
Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
07:08

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis

Published on: August 31, 2022

1.6K
Dual Immunofluorescence of γH2AX and 53BP1 in Human Peripheral Lymphocytes
05:34

Dual Immunofluorescence of γH2AX and 53BP1 in Human Peripheral Lymphocytes

Published on: July 14, 2023

2.7K

Area of Science:

  • Hematology
  • Oncology
  • Epidemiology

Background:

  • Myelodysplastic syndromes (MDS) are hematological neoplasms characterized by ineffective hematopoiesis and dysplasia.
  • MDS can arise de novo or secondary to treatments like chemoradiotherapy, increasing acute leukemia risk.
  • Previous studies on atomic bomb survivors have provided insights into leukemia risk factors.

Purpose of the Study:

  • To review and discuss factors influencing the risk of myelodysplastic syndromes (MDS), particularly secondary MDS.
  • To compare epidemiological data of secondary MDS with leukemia/MDS in atomic bomb survivors.
  • To elucidate the impact of external radiation exposure on MDS development.

Main Methods:

  • Epidemiological analysis of myelodysplastic syndromes (MDS) in atomic bomb survivors.
  • Comparative review of secondary MDS and leukemia/MDS data.
  • Identification and discussion of clinical factors associated with MDS risk.

Main Results:

  • Epidemiological studies clearly demonstrate that external radiation exposure significantly elevates the risk of MDS.
  • Precise data from survivors highlight key clinical factors influencing leukemia risk.
  • Comparative analysis reveals specific factors affecting secondary MDS development.

Conclusions:

  • External radiation is a significant risk factor for myelodysplastic syndromes (MDS).
  • Understanding risk factors for secondary MDS is crucial for patient management and prevention.
  • Further research comparing secondary MDS and leukemia/MDS in radiation-exposed populations is warranted.