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A Patient-Derived Xenograft Model for Venous Malformation
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Other vascular tumors.

Denise M Adams1, Adrienne Hammill2

  • 1Cancer and Blood Disease Institute, Cincinnati Children׳s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio; Hemangioma and Vascular Malformation Center, Cincinnati Children׳s Hospital Medical Center, 3333 Burnett Ave, Cincinnati, Ohio, 45229.

Seminars in Pediatric Surgery
|September 22, 2014
PubMed
Summary
This summary is machine-generated.

Vascular tumors in children are rare and challenging to classify. Recent updates classify intermediate tumors as locally aggressive or rarely metastasizing, requiring multidisciplinary care.

Keywords:
AngiosarcomaBenign vascular tumorsEpithelioid hemangioendothelioma (EHE)Intermediate vascular tumorsKaposiform hemangioendothelioma (KHE)Kasabach–Merritt phenomenon (KMP)Malignant vascular tumors

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Area of Science:

  • Vascular oncology
  • Pediatric pathology

Background:

  • Vascular tumors are uncommon in both pediatric and adult populations.
  • Classification challenges arise from rarity, variable morphology, and diverse clinical behaviors, particularly in children.
  • The 2013 World Health Organization classification of soft tissue vascular tumors did not independently stratify pediatric cases.

Purpose of the Study:

  • To address the difficulties in classifying pediatric vascular tumors.
  • To highlight the implications of the 2013 WHO classification on pediatric vascular tumor management.
  • To emphasize the need for specialized care in treating these rare lesions.

Main Methods:

  • Review of the 2013 World Health Organization classification of soft tissue vascular tumors.
  • Analysis of challenges in pediatric vascular tumor diagnosis and stratification.
  • Discussion of treatment modalities and the importance of interdisciplinary teams.

Main Results:

  • The 2013 WHO classification maintained much of the previous terminology for vascular tumors.
  • The intermediate category of vascular tumors was reclassified into 'locally aggressive' and 'rarely metastasizing' subtypes.
  • Pediatric vascular tumors were not given independent stratification within this update.

Conclusions:

  • Accurate classification of pediatric vascular tumors remains a challenge.
  • The updated classification necessitates careful consideration for pediatric cases.
  • Multimodality therapy and interdisciplinary team guidance are crucial for optimal management of pediatric vascular tumors.