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Related Experiment Videos

Bullous pemphigoid associated with captopril.

L Mallet1, J W Cooper, J Thomas

  • 1Geriatric Pharmacotherapy, University of Georgia, Athens.

DICP : the Annals of Pharmacotherapy
|January 1, 1989
PubMed
Summary

Captopril, a common hypertension drug, can cause skin reactions. This case highlights bullous pemphigoid developing on a patient's palms after captopril use, resolving with treatment.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Internal Medicine

Background:

  • Captopril is a widely used angiotensin-converting enzyme (ACE) inhibitor for hypertension and heart failure.
  • Dermatological side effects are known complications of captopril therapy, affecting approximately 10% of patients.
  • Bullous pemphigoid is an autoimmune blistering disease that can be drug-induced.

Observation:

  • A 77-year-old female patient developed localized bullous eruptions on her palms.
  • The onset of these lesions occurred approximately 50 days after initiating captopril 25 mg twice daily.
  • Clinical presentation and biopsy findings were consistent with bullous pemphigoid.

Findings:

  • The case report documents a direct association between captopril use and the development of bullous pemphigoid.
  • Discontinuation of captopril therapy was followed by lesion healing.
  • Concurrent oral corticosteroid treatment facilitated the resolution of the dermatological manifestations.

Implications:

  • This case underscores the importance of considering drug-induced bullous pemphigoid in patients presenting with new-onset blistering disorders.
  • Physicians should be vigilant for dermatological adverse reactions, including bullous pemphigoid, in patients taking captopril.
  • Prompt recognition and management, including drug withdrawal and appropriate therapy, are crucial for favorable patient outcomes.

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