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Characteristics of group B Streptococcus isolated from infants with invasive infections: a population-based study in

Bin Chang1, Akihito Wada, Mitsuaki Hosoya

  • 1Department of Bacteriology I, National Institute of Infectious Diseases.

Japanese Journal of Infectious Diseases
|September 23, 2014
PubMed

Insights

Group B Streptococcus (GBS) causes neonatal infections in Japan. Serotypes III, Ia, and Ib were most common, with GBS remaining susceptible to penicillin and related antibiotics.

Area of Science:

  • Microbiology
  • Epidemiology
  • Neonatal Health

Background:

  • Group B Streptococcus (GBS) is a primary cause of invasive bacterial infections in newborns.
  • Neonatal infections pose significant health risks globally.
  • Surveillance data on GBS in Japan is crucial for public health strategies.

Purpose of the Study:

  • To conduct population-based surveillance of GBS invasive diseases in Japanese newborns and infants.
  • To characterize the epidemiology and antimicrobial resistance patterns of GBS isolates.
  • To identify specific GBS serotypes and sequence types associated with invasive infections.

Main Methods:

  • Population-based surveillance across 10 Japanese prefectures from 2007 to 2012.
  • Collection and analysis of GBS isolates from 60 invasive cases.
  • Serotyping, antimicrobial susceptibility testing, and multilocus sequence typing (MLST).

Main Results:

  • The incidence rate of GBS invasive diseases was 0.13 per 1,000 live births.
  • Serotypes III, Ia, and Ib accounted for over 80% of invasive infections.
  • All GBS isolates were susceptible to beta-lactam antibiotics; however, resistance to erythromycin and clindamycin was observed.

Conclusions:

  • Serotypes III, Ia, and Ib are the predominant GBS serotypes causing invasive infections in Japanese infants.
  • GBS strains in Japan remain highly susceptible to beta-lactam antibiotics, indicating their continued efficacy.
  • Specific sequence types (ST 23, ST 17, ST 335) were linked to increased meningitis incidence.

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