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Developmental cerebellar cognitive affective syndrome in ex-preterm survivors following cerebellar injury

Marie Brossard-Racine1, Adre J du Plessis, Catherine Limperopoulos

  • 1Advanced Pediatric Brain Imaging Research Laboratory, Children's National Health System, Washington, DC, USA, mbracine@cnmc.org.

Cerebellum (London, England)
|September 23, 2014
PubMed

Insights

Cerebellar injury in premature infants impacts neurodevelopment beyond motor skills. Early cerebellar growth impairment contributes to long-term cognitive, behavioral, and social deficits.

Area of Science:

  • Neuroscience
  • Developmental Pediatrics
  • Neonatology

Background:

  • Cerebellar injury is a recognized complication in very preterm infants.
  • Neurodevelopmental outcomes following early cerebellar injury are not fully understood.
  • The review focuses on direct and indirect cerebellar injury in preterm infants.

Purpose of the Study:

  • To review the neurodevelopmental consequences of early life cerebellar injury in prematurely born infants.
  • To explore the relationship between cerebellar injury and cognitive, behavioral, and social deficits.
  • To highlight the role of cerebellar growth impairment in long-term outcomes.

Main Methods:

  • Literature search of studies published between 1997 and 2014.
  • Analysis of studies describing neurodevelopmental outcomes in preterm infants with cerebellar injury.
  • Synthesis of data on direct and indirect cerebellar injury mechanisms and effects.

Main Results:

  • Both direct and indirect cerebellar injury mechanisms stunt cerebellar growth.
  • Early cerebellar injury adversely affects neurodevelopment, extending beyond motor impairments.
  • Evidence suggests a developmental form of the cerebellar cognitive affective syndrome in preterm infants.

Conclusions:

  • Early life cerebellar growth impairment significantly contributes to long-term cognitive, behavioral, and social deficits in premature infants.
  • Cerebellar injury plays a critical, underrecognized role in the neurodevelopmental dysfunction associated with preterm birth.
  • Further longitudinal studies using advanced neuroimaging are needed to fully understand prematurity-related cerebellar injury's impact.

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