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Updated: Apr 23, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
Published on: April 7, 2023
8th Pieter van Keep Memorial Lecture. Estrogen and bone: have we completed a full circle?
1Past President, International Menopause Society, Mediclinic Panorama and Department of Obstetrics and Gynecology, Stellenbosch University , Cape Town , South Africa.
Abstract:
Estrogen therapy was considered first-line therapy for the prevention and treatment of postmenopausal osteoporosis in 1984. Evidence from a large, randomized clinical trial in 2002 proved the efficacy of estrogen in the prevention of all types of osteoporosis-related fractures. Ironically, estrogen was relegated to second-line therapy, based on perceived safety concerns. The historical background to these decisions is presented. It is argued that this decision is not a reasonable reflection of the available evidence, especially in comparison to other available drugs.
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