Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is traditional Chinese medicine service accessibility associated with health inequality? Evidence from the distribution of health capital among rural residents in China.

International journal for equity in health·2026
Same author

Capturing Elusive Volatile Organics in Atmospheric Particles via Dual-Mode Solid-Phase Microextraction Coupled with Gas Chromatography-Orbitrap Mass Spectrometry.

Analytical chemistry·2026
Same author

Biocompatible Interface for Organic Electrochemical Transistors Enables Bioadhesion and Over-Swelling Suppression.

Angewandte Chemie (International ed. in English)·2026
Same author

Cysteine-rich secreted protein OsCRRSP1 enhances rice defense through dual inhibition of pathogen and host catalases.

Plant communications·2026
Same author

Comparative assessment of image quality and radiation dose: spectral purification computed tomography (Sn100kV) with adaptive iterative reconstruction for tuberculosis follow-up.

Journal of thoracic disease·2026
Same author

Application value of isotropic acquisition with simultaneous multi-slice diffusion weighted imaging in subacute early small artery occlusive cerebral infarction.

Frontiers in neurology·2026

Related Experiment Video

Updated: Apr 23, 2026

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
05:24

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

1.7K

High performance and reversible ionic polypeptide hydrogel based on charge-driven assembly for biomedical

Haitao Cui1, Xiuli Zhuang2, Chaoliang He2

  • 1Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; University of Chinese Academy of Sciences, Beijing 100039, PR China.

Acta Biomaterialia
|September 23, 2014
PubMed
Summary
This summary is machine-generated.

Researchers developed biodegradable hydrogels using ionic polypeptides for drug delivery and tissue engineering. These adaptable materials demonstrate excellent cytocompatibility and in vivo biocompatibility, offering a promising platform for biomedical applications.

Keywords:
Charge-drivenInjectable hydrogelIonic polypeptidesReversible response

More Related Videos

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.3K
The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

10.8K

Related Experiment Videos

Last Updated: Apr 23, 2026

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
05:24

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

1.7K
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.3K
The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

10.8K

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Developing physically associated hydrogels with tunable properties is crucial for advanced applications.
  • Dynamic materials utilizing electrostatic interactions offer a promising route for hydrogel design.
  • Ionic polypeptides present a versatile platform for creating functional biomaterials.

Purpose of the Study:

  • To introduce a novel strategy for synthesizing biodegradable hydrogels from ABA triblock ionic polypeptides.
  • To investigate the physical properties, cytocompatibility, and in vivo performance of these novel hydrogels.
  • To establish the potential of these hydrogels as injectable materials for biomedical applications.

Main Methods:

  • Synthesis of ABA triblock ionic polypeptides: poly(L-glutamic acid)-block-poly(ethylene glycol)-block-poly(L-glutamic acid) (PGA-PEG-PGA) and poly(L-lysine)-block-poly(ethylene glycol)-block-poly(L-lysine) (PLL-PEG-PLL).
  • Formation of hydrogels through electrostatic interactions between oppositely charged polypeptide blocks.
  • Characterization of hydrogel properties, including mechanical strength, reversibility, and drug/protein conjugation.
  • Assessment of cytocompatibility using cell encapsulation and viability assays.
  • In vivo evaluation in rats via subcutaneous injection, including degradation studies and histological analysis (hematoxylin and eosin staining).

Main Results:

  • Successfully synthesized biodegradable hydrogels from PGA-PEG-PGA and PLL-PEG-PLL via electrostatic interactions.
  • Achieved tunable physical properties, high strength, and reversible responses in the hydrogels.
  • Demonstrated successful conjugation of drugs/proteins with reactive functional groups and effective cell encapsulation with high viability.
  • Confirmed in vivo hydrogel formation, degradation, and good biocompatibility in rat models.
  • Validated the potential for these hydrogels as injectable materials for biomedical applications.

Conclusions:

  • Ionic ABA triblock polyelectrolytes provide a versatile and effective cross-linking system for creating injectable hydrogels.
  • The synthesized hydrogels exhibit desirable properties including biodegradability, tunable mechanics, and excellent cytocompatibility.
  • This cross-linking strategy offers a flexible and powerful new tool for developing advanced hydrogels for diverse biomedical applications, including drug delivery and tissue engineering.