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Interactions between phospholipids and titanium dioxide particles.

Quoc-Chon Le¹, Marie-Hélène Ropers², Hélène Terrisse¹

¹Institut Matériaux Jean Rouxel IMN, UMR 6502, Univ Nantes, CNRS, F-44322 Nantes 3, France.

Colloids and Surfaces. B, Biointerfaces

|September 23, 2014

Summary

This summary is machine-generated.

Titanium dioxide (TiO2) particles interact selectively with certain phospholipids, driven primarily by electrostatic forces. Non-electrostatic interactions also occur, depending on lipid structure, influencing binding to TiO2 surfaces.

Keywords:

Langmuir film Phospholipid Pressure-area isotherm Surface charge Titanium dioxide Zeta potential

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Area of Science:

Materials Science
Surface Chemistry
Biophysics

Background:

Titanium dioxide (TiO2) nanoparticles are widely used, necessitating understanding their interactions with biological molecules.
Lipid-protein and lipid-nanoparticle interactions are crucial for biological membrane function and nanoparticle safety assessments.

Purpose of the Study:

To investigate the interactions between titanium dioxide (TiO2-P25) particles and various membrane lipids.
To determine the driving forces (electrostatic and non-electrostatic) and pH-dependent behavior of these interactions.

Main Methods:

Utilized Langmuir trough to record pressure-area isotherms of lipids with and without TiO2-P25 and NaCl.
Measured electrophoretic mobilities of lipid vesicles and TiO2-P25 particles to assess electrostatic interactions across different pH values.

Main Results:

TiO2-P25 particles selectively interact with specific phospholipids, not all membrane lipids.
Electrostatic interactions are the primary driving force, occurring when lipids and TiO2-P25 have opposite charges (pH 2-6.6).
Non-electrostatic interactions, potentially via glycerol hydroxyl groups or carboxylate groups, were observed for certain lipids (TMCL, DMPG, DMPS) under less favorable electrostatic conditions.

Conclusions:

Specific phospholipids like DMPA, DMPG, and TMCL show strong electrostatic binding to TiO2-P25 within a defined pH range.
Lipids such as DMPS and DHP exhibit weaker interactions, involving carboxylate groups.
Lipids lacking charged headgroups (DMPC, DMPE, SM) do not interact with TiO2-P25, highlighting the specificity of lipid-TiO2 interactions.