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Published on: June 5, 2019
Increased intracranial pressure in mini-pigs exposed to simulated solar particle event radiation
Jk Sanzari1, A Muehlmatt1, A Savage1
1Department of Radiation Oncology, 3620 Hamilton Walk, 183 John Morgan Building, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Abstract:
Changes in intracranial pressure (ICP) during space flight have stimulated an area of research in space medicine. It is widely speculated that elevations in ICP contribute to structural and functional ocular changes, including deterioration in vision, which is also observed during space flight. The aim of this study was to investigate changes in OP occurring as a result of ionizing radiation exposure (at doses and dose-rates relevant to solar particle event radiation). We used a large animal model, the Yucatan mini-pig, and were able to obtain measurements over a 90 day period. This is the first investigation to show long term recordings of ICP in a large animal model without an invasive craniotomy procedure. Further, this is the first investigation reporting increased ICP after radiation exposure.
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