Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.8K
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

829
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
829
Applications of Molecular Taxonomy01:20

Applications of Molecular Taxonomy

702
Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
702
RNA-seq03:21

RNA-seq

9.2K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
9.2K
High-Resolution Mass Spectrometry (HRMS)01:15

High-Resolution Mass Spectrometry (HRMS)

2.6K
The resolution of a mass spectrometer depends on the efficiency of separating ions with different ion masses. The mass of an atom is approximated to the sum of the masses of protons and neutrons inside, considering the masses of protons and neutrons as equal. However, the masses of the proton (1.6726 × 10−24 g) and neutron (1.6749 × 10−24 g) are not truly equal. There is a minor error in the expression of atomic masses relative to the simplest atom of hydrogen. For...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ovarian cancer tumor immune profiles associated with intrauterine device and oral contraceptive use.

British journal of cancer·2026
Same author

Spatial Clustering of Recently Activated Cytotoxic Lymphocytes Improves Association with Overall Survival in Women with High-Grade Serous Ovarian Cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2026
Same author

<i>Brca1</i> heterozygosity leads to hepatic steatosis in male and female mice despite sexually dimorphic effects on systemic metabolism.

bioRxiv : the preprint server for biology·2026
Same author

Spatial Clustering of Recently Activated Cytotoxic Lymphocytes Improves Association with Overall Survival in Women with High-Grade Serous Ovarian Cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2026
Same author

FastPCA: An R package for fast singular value decomposition.

Journal of open source software·2026
Same author

scSpatialSIM: a simulator of spatial single-cell molecular data.

SoftwareX·2026
Same journal

Identification of chondroitin polymerizing factor as a biomarker for predicting immunotherapy response in breast cancer: a bioinformatics analysis of tumor microenvironment.

Translational cancer research·2026
Same journal

Neuro-glioma activity-dependent growth mechanisms: an actionable circuit from NLGN3-ADAM10 to AMPA synapses.

Translational cancer research·2026
Same journal

Association of serum vitamins and carotenoids with breast cancer status among adult women in NHANES 2017-2018: a cross-sectional study.

Translational cancer research·2026
Same journal

Development and validation of prognostic nomograms for patients with cervical cancer and liver metastasis: a SEER-based study.

Translational cancer research·2026
Same journal

Epcoritamab plus gemcitabine and oxaliplatin in transplant-ineligible relapsed/refractory diffuse large B-cell lymphoma: how should this regimen be positioned in current treatment algorithms?

Translational cancer research·2026
Same journal

Circadian-immune-related gene signature for lung squamous cell carcinoma: machine learning and multi-omics analysis.

Translational cancer research·2026
See all related articles

Related Experiment Video

Updated: Apr 23, 2026

ExCYT: A Graphical User Interface for Streamlining Analysis of High-Dimensional Cytometry Data
05:12

ExCYT: A Graphical User Interface for Streamlining Analysis of High-Dimensional Cytometry Data

Published on: January 16, 2019

11.2K

Integrative clustering methods for high-dimensional molecular data.

Prabhakar Chalise1, Devin C Koestler1, Milan Bimali1

  • 1Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS 66160, USA.

Translational Cancer Research
|September 23, 2014
PubMed
Summary
This summary is machine-generated.

High-throughput omics data aids disease understanding. Integrative clustering methods for multiple omics data types are crucial for discovering novel molecular subtypes, improving patient stratification.

Keywords:
Consensus clusteringcophenetic correlationlatent modelsmixture modelsnon-negative matrix factorization

More Related Videos

Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations
12:27

Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations

Published on: February 15, 2017

6.2K
Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
11:14

Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry

Published on: October 2, 2016

12.9K

Related Experiment Videos

Last Updated: Apr 23, 2026

ExCYT: A Graphical User Interface for Streamlining Analysis of High-Dimensional Cytometry Data
05:12

ExCYT: A Graphical User Interface for Streamlining Analysis of High-Dimensional Cytometry Data

Published on: January 16, 2019

11.2K
Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations
12:27

Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations

Published on: February 15, 2017

6.2K
Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
11:14

Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry

Published on: October 2, 2016

12.9K

Area of Science:

  • Genomics and Bioinformatics
  • Computational Biology
  • Translational Medicine

Background:

  • High-throughput omics data (gene expression, DNA methylation, copy number) advances understanding of human health and disease.
  • Molecular profiles can vary significantly between cells with similar morphology, impacting patient outcomes.
  • Identifying novel molecular subtypes is crucial for personalized medicine and understanding disease heterogeneity.

Purpose of the Study:

  • To systematically review existing integrative clustering methods for multiple omics data types.
  • To highlight the potential of integrative clustering for molecular subtype discovery in complex diseases.
  • To address limitations of single omics clustering and traditional manual data integration.

Main Methods:

  • Systematic literature review of integrative clustering methods.
  • Analysis of methods designed for simultaneous clustering of multiple omics data types.
  • Comparison with traditional approaches for omics data integration.

Main Results:

  • Numerous clustering methods exist, but many are designed for single omics data types.
  • Integrative clustering offers a rigorous framework for simultaneous multi-omics analysis.
  • Traditional manual integration of individual omics clustering results can lead to inconsistent subtype assignments.

Conclusions:

  • Integrative clustering methods are essential for leveraging multi-omics data to discover robust molecular subtypes.
  • These methods hold significant potential for advancing the understanding and treatment of complex diseases like cancer.
  • Further development and application of integrative clustering are needed to fully realize the potential of multi-omics data.