Related Experiment Video

Updated: Apr 23, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

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The potential of microRNAs in personalized medicine against cancers

Anne Saumet1, Anthony Mathelier2, Charles-Henri Lecellier3

  • 1Université Montpellier 1, 5 Bd Henri IV, 34967 Montpellier Cedex 2, France.

Biomed Research International
|September 23, 2014
PubMed

Insights

MicroRNAs regulate gene expression and are crucial in cancer development and progression. Targeting microRNAs offers new therapeutic strategies and diagnostic tools for personalized cancer medicine.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression.
  • Dysregulation of miRNAs is implicated in the initiation, progression, metastasis, and therapeutic resistance of various human cancers.
  • miRNAs play a significant role in cellular processes, making them key players in tumorigenesis.

Purpose of the Study:

  • To review the multifaceted roles of microRNAs in cancer biology.
  • To highlight microRNAs as potential therapeutic targets for novel anticancer strategies.
  • To discuss the application of microRNA profiles in cancer diagnosis, prognosis, and theranosis.

Main Methods:

  • Literature review of studies on microRNA biology and cancer.
  • Analysis of microRNA involvement in tumorigenesis stages.
  • Examination of microRNA-based diagnostic and therapeutic approaches.

Main Results:

  • MicroRNAs are critical regulators of gene expression and cellular functions.
  • Aberrant miRNA expression is a hallmark of many human cancers.
  • miRNA profiles serve as valuable tumor-specific signatures for cancer detection and management.

Conclusions:

  • MicroRNAs are pivotal molecules in cancer development and progression.
  • Restoring miRNA expression or function presents a promising avenue for cancer therapy.
  • MicroRNAs are integral to personalized medicine for cancer diagnosis, prognosis, and treatment monitoring.

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