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Related Experiment Video

Updated: Apr 23, 2026

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

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Aluminium involvement in neurotoxicity.

Alessandro Fulgenzi¹, Daniele Vietti¹, Maria Elena Ferrero¹

¹Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Via Luigi Mangiagall, 31, 20133 Milano, Italy.

Biomed Research International

|September 23, 2014

Summary

This study investigated aluminium (Al) intoxication in neurodegenerative diseases (ND). Chelation therapy using EDTA effectively reduced Al levels in patients with ND, suggesting a link between Al burden and these conditions.

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Area of Science:

Environmental toxicology
Neuroscience
Clinical medicine

Background:

Neurodegenerative diseases (ND) likely result from genetic and environmental factors.
Toxic metals are significant environmental pollutants.
Previous work noted improvement in multiple sclerosis (MS) after toxic metal removal.

Purpose of the Study:

To investigate the potential link between aluminum (Al) intoxication and neurodegenerative diseases.
To assess the efficacy of chelation therapy in reducing Al burden in ND patients.

Main Methods:

A chelation test using intravenous ethylenediamine tetraacetic acid (EDTA) was employed to measure Al excretion in urine over 12 hours.
Patients with various ND, including MS, and healthy controls were assessed.
Treatment involved ten weekly intravenous EDTA chelation therapies for patients with confirmed Al burden.

Main Results:

Aluminum was detected in 44.8% of all subjects (ND and healthy).
Al levels were significantly higher in patients with neurodegenerative diseases compared to healthy individuals.
Multiple sclerosis patients constituted 85.6% of the total ND cohort.
EDTA chelation therapy significantly reduced Al intoxication in treated patients.

Conclusions:

Elevated aluminum levels are associated with neurodegenerative diseases.
EDTA chelation therapy is effective in reducing aluminum burden.
Further research into the role of aluminum in ND etiology is warranted.