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Allergic contact sensitivity to quinophthalone.
H Komamura1, T Kozuka, M Ishii
1Department of Dermatology, Osaka University School of Medicine, Japan.
Contact Dermatitis
|March 1, 1989
Summary
A patient with seborrheic dermatitis experienced a reaction to a hair stick. Chemical analysis identified D&C Yellow No. 11, specifically quinophthalone, as the causative agent in the hair product.
Area of Science:
- Dermatology
- Cosmetic Science
- Analytical Chemistry
Background:
- Seborrheic dermatitis is a common inflammatory skin condition.
- Hair preparations can sometimes cause contact dermatitis.
- Patch testing is crucial for identifying specific allergens in cosmetic products.
Observation:
- A 73-year-old patient diagnosed with seborrheic dermatitis presented with a positive patch test reaction to a hair stick.
- Further investigation revealed that D&C Yellow No. 11 and perfume within the hair stick were the primary irritants.
Findings:
- Chemical analysis confirmed D&C Yellow No. 11 consists solely of quinophthalone.
- High-performance liquid chromatography determined the concentration of quinophthalone in the hair stick to be 9.41 ppm w/w.
- The positive reactions occurred at concentrations of D&C Yellow No. 11 ranging from 0.0001% to 0.1%.
Implications:
- Identifies quinophthalone as a potential contact allergen in hair products.
- Highlights the importance of ingredient transparency in cosmetic formulations.
- Informs dermatologists and patients about potential triggers for hair product-induced dermatitis.