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Senile erythroderma with serum hyper IgE.

T Asai¹, Y Horiuchi

¹Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan.

International Journal of Dermatology

|May 1, 1989

Summary

Senile erythroderma with hyperimmunoglobulinemia E (hyper IgE) presents with elevated IgE, eosinophils, and LDH. Immunologic analysis revealed IgE in lymph node germinal centers, suggesting hereditary factors in some patients.

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Area of Science:

Immunology
Dermatology
Geriatrics

Background:

Senile erythroderma is a dermatological condition affecting the elderly.
Elevated serum immunoglobulin E (IgE) levels can be associated with various conditions, including allergic and non-allergic disorders.

Purpose of the Study:

To investigate the clinical and immunologic characteristics of senile erythroderma associated with hyperimmunoglobulinemia E (hyper IgE).

Main Methods:

Studied eight patients diagnosed with senile erythroderma and elevated serum IgE.
Performed laboratory tests including IgE levels, peripheral-blood eosinophil counts, and lactic dehydrogenase (LDH) measurements.
Conducted immunologic analysis on inguinal lymph node biopsies using anti-IgE antibody staining.

Main Results:

Patients exhibited persistently elevated IgE levels, high peripheral-blood eosinophils, and elevated LDH.
Immunologic analysis showed significant staining with anti-IgE antibody in the germinal centers of inguinal lymph nodes.
Five out of eight patients reported a history of atopy.

Conclusions:

Senile erythroderma with hyper IgE is characterized by specific laboratory findings and localized IgE deposition in lymph nodes.
The presence of atopic history in a subset of patients suggests a potential role for hereditary factors in the pathogenesis of this condition.

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