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Low familial risks for multiple sclerosis in Buenos Aires, Argentina
Mauricio F Farez1, María E Balbuena Aguirre2, Francisco Varela1
1Department of Neurology, Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina.
Journal of the Neurological Sciences
|September 24, 2014
Summary
Familial multiple sclerosis (MS) risk is elevated in Argentina. Daughters of MS patients face a significantly higher risk, though overall familial risk is lower than in other regions.
Area of Science:
- Neurology
- Genetics
- Epidemiology
Background:
- Multiple sclerosis (MS) is a complex neurological disease with recognized genetic susceptibility.
- Familial occurrence of MS is established, but unstudied in Argentina, a low-to-intermediate prevalence region.
Purpose of the Study:
- To investigate the familial occurrence and recurrence risk of multiple sclerosis in Argentina.
- To assess the genetic susceptibility and risk patterns within Argentine families affected by MS.
Main Methods:
- A cross-sectional study collected pedigree data from 219 multiple sclerosis patients in Buenos Aires.
- Recurrence risks for relatives were assessed using crude and age-adjusted analyses on 4227 individuals.
Main Results:
- Ten percent of MS patients reported at least one affected relative.
- Daughters of MS patients exhibited the highest risk (1.54%), a 92-fold increase compared to the general population.
- Sibling recurrence risk ratios were comparable to international findings.
Conclusions:
- Relatives of individuals with MS in Argentina have an increased risk of developing the disease.
- While familial risk is elevated, it appears lower than reported in other geographic areas globally.
Keywords:
ArgentinaFamilial riskMultiple sclerosisRecurrence riskSibling recurrence-riskSouth AmericaMore Related Videos
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