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Related Concept Videos

Jaundice01:25

Jaundice

26
Jaundice, or icterus, is the yellow discoloration of the skin, sclerae, and mucous membranes. It happens when plasma bilirubin levels rise above 2.5-3 mg/dL, leading to bilirubin deposition in tissue.Bilirubin is a byproduct of hemoglobin degradation. In macrophages, hemoglobin breaks down into globin and heme. Globin is converted into amino acids, while heme is turned into biliverdin by heme oxygenase, which is then reduced to unconjugated bilirubin by biliverdin reductase.Unconjugated...
26
Immunofluorescence Microscopy01:12

Immunofluorescence Microscopy

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A fluorescence microscope uses fluorescent chromophores called fluorochromes, which can absorb energy from a light source and then emit this energy as visible light. Fluorochromes include naturally fluorescent substances (such as chlorophylls) and fluorescent stains that are added to the specimen to create contrast. Dyes such as Texas red and FITC are examples of fluorochromes. Other examples include the nucleic acid dyes 4’,6’-diamidino-2-phenylindole (DAPI), and acridine orange.
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Conjugated Proteins02:50

Conjugated Proteins

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Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
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Conjugated Proteins

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UV–Vis Spectroscopy of Conjugated Systems01:32

UV–Vis Spectroscopy of Conjugated Systems

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Organic compounds with conjugated double bonds show strong absorption features in the UV–visible region of the electromagnetic spectrum attributed to π → π* electronic excitations. Generally, a UV–vis absorption spectrum is recorded as a plot of absorbance vs wavelength. The wavelength of maximum absorbance, which manifests as a peak in the absorption spectrum, is denoted as λmax.
One of the factors influencing λmax is...
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FISH - Fluorescent In-situ Hybridization02:07

FISH - Fluorescent In-situ Hybridization

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Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...
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Related Experiment Video

Updated: Apr 23, 2026

Fluorescent Laparoscopic Central Hepatectomy for Liver Cancer Using Indocyanine Green Negative Staining
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Fluorescein-related extensive jaundice.

Asim Kalkan1, Suleyman Turedi2, Ibrahim Aydin3

  • 1Recep Tayyip Erdogan University Faculty of Medicine, Department of Emergency Medicine, Rize, Turkey.

The American Journal of Emergency Medicine
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Summary

Fluorescein angiography, used for eye exams, can rarely cause jaundice. Emergency physicians should consider this dye as a potential cause in patients presenting with jaundice post-procedure.

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Area of Science:

  • Ophthalmology
  • Medical Diagnostics

Background:

  • Fluorescein angiography is a standard diagnostic tool for evaluating ocular vascular diseases.
  • While fluorescein dye has known adverse effects, jaundice has not been a previously reported complication.

Observation:

  • A 65-year-old woman developed extensive jaundice hours after fluorescein angiography for vision impairment.
  • Initial diagnostic tests for common causes of jaundice were negative.

Findings:

  • The patient was diagnosed with fluorescein-induced jaundice.
  • This case highlights a rare but potential adverse effect of fluorescein angiography.

Implications:

  • Clinicians should consider fluorescein dye as a rare cause of jaundice in patients presenting post-angiography.
  • Detailed patient history, including recent procedures, is crucial for diagnosing unusual drug-induced conditions.