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The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
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Related Experiment Video

Updated: Apr 23, 2026

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
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Pregnancy testing with hCG--future prospects.

Peter Berger1, Catharine Sturgeon2

  • 1Institute for Biomedical Aging Research, University of Innsbruck, Rennweg 10, A6020 Innsbruck, Austria.

Trends in Endocrinology and Metabolism: TEM
|September 24, 2014
PubMed
Summary
This summary is machine-generated.

Reliable human chorionic gonadotrophin (hCG) measurement is crucial for pregnancy tests, prenatal screening, and oncology. New standards and reference materials ensure accurate hCG testing, improving patient safety by reducing misleading results.

Keywords:
antibody standardisationfifth IS 07/364 for hCGfirst IRR for hCGhCG variantspregnancy testing

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Area of Science:

  • Clinical Chemistry
  • Biotechnology
  • Immunoassays

Background:

  • Human chorionic gonadotrophin (hCG) assays are vital in clinical diagnostics, including pregnancy testing, prenatal screening, and oncology.
  • Current hCG assays require standardization to ensure reliable and comparable results across different settings.

Purpose of the Study:

  • To establish a framework for reliable measurement of human chorionic gonadotrophin (hCG).
  • To define requirements for future hCG assay development and characterization.

Main Methods:

  • Utilized outputs from three international workshops on hCG measurement.
  • Proposed standardized nomenclature, antibody selection criteria, and robust assay design.
  • Emphasized calibration using International Reference Reagents (IRR) and International Standards for hCG.

Main Results:

  • A framework for reliable hCG measurement has been developed.
  • Future assays will be characterized and calibrated in SI units.
  • Reporting clinical results in molar units will become possible.

Conclusions:

  • Standardized hCG measurement enhances accuracy and comparability of diagnostic tests.
  • Implementation of these measures will improve patient safety by minimizing erroneous hCG results.
  • Adoption of these guidelines will advance the field of hCG diagnostics.