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NAIL, a software toolset for inferring, analyzing and visualizing regulatory networks.

Daniel G Hurley1, Joseph Cursons2, Yi Kan Wang2

  • 1Auckland Bioengineering Institute, University of Auckland, Auckland 1001, New Zealand, Department of Molecular Medicine and Pathology, School of Medical Sciences, Faculty of Medical and Health Sciences,University of Auckland, Auckland 1001, New Zealand, Bioinformatics Institute, University of Auckland, Auckland 1001, New Zealand, Maurice Wilkins Centre, University of Auckland, Auckland 1001, New Zealand, Systems Biology Laboratory, Melbourne School of Engineering, University of Melbourne, Victoria 3010, Australia, Department of Mathematics and Statistics, University of Melbourne School of Medicine, University of Melbourne, Victoria 3010, Australia and Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, Canada Auckland Bioengineering Institute, University of Auckland, Auckland 1001, New Zealand, Department of Molecular Medicine and Pathology, School of Medical Sciences, Faculty of Medical and Health Sciences,University of Auckland, Auckland 1001, New Zealand, Bioinformatics Institute, University of Auckland, Auckland 1001, New Zealand, Maurice Wilkins Centre, University of Auckland, Auckland 1001, New Zealand, Systems Biology Laboratory, Melbourne School of Engineering, University of Melbourne, Victoria 3010, Australia, Department of Mathematics and Statistics, University of Melbourne School of Medicine, University of Melbourne, Victoria 3010, Australia and Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, Canada Auckland Bioengineering Institute, University of Auckland, Auckland 1001, New Zealand, Department of Molecular Medicine and Pathology, School of Medical Sciences, Faculty of Medical and Health Sciences,University of Auckland, Auckland 1001, New Zealand, Bioinformatics Institute, University of Auckland, Auckland 1001, New Zealand, Maurice Wilkins Centre, University of Auckland, Auckland 1001, New Zealand, Systems Biology Laboratory, Melbourne School of Engineering, University of Melbourne, Victoria 3010, Aus

Bioinformatics (Oxford, England)
|September 24, 2014
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Summary

The Network Analysis and Inference Library (NAIL) simplifies complex regulatory network inference by offering a modular software toolkit. This tool integrates various inference algorithms for unified analysis and visualization, saving researchers time.

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Area of Science:

  • Computational Biology
  • Systems Biology
  • Bioinformatics

Background:

  • Regulatory network inference is computationally intensive due to diverse algorithms.
  • Integrating multiple inference methods is complex and time-consuming for researchers.

Purpose of the Study:

  • To introduce the Network Analysis and Inference Library (NAIL) as a solution for simplifying regulatory network inference.
  • To provide a modular and technology-independent software toolkit for computational network analysis.

Main Methods:

  • NAIL employs a modular architecture to connect diverse network inference algorithms.
  • The library facilitates unified visualization and network-based analyses.
  • It features an interface layer for seamless integration into other applications.

Main Results:

  • NAIL streamlines the computational workflow for regulatory network inference.
  • The software enables the use of multiple inference algorithms within a single framework.
  • It supports technology-independent integration and analysis.

Conclusions:

  • NAIL significantly reduces the complexity and time required for regulatory network inference.
  • The library promotes efficient and comprehensive analysis of biological networks.
  • NAIL is freely available for researchers to enhance their systems biology studies.