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Pertussis immunization in infancy and adolescent asthma medication
Hartmut Vogt1, Lennart Bråbäck2, Anna-Maria Kling3
1Department of Paediatrics and Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden hartmut.vogt@liu.se.
Pediatrics
|September 24, 2014
Summary
Infant pertussis immunization does not increase adolescent asthma medication use. This study suggests childhood pertussis vaccination is safe for long-term asthma development.
Area of Science:
- Pediatric immunology
- Respiratory medicine
- Vaccinology
Background:
- Childhood immunization may impact asthma development through altered immune responses.
- The relationship between pertussis vaccination and asthma risk requires further investigation.
Purpose of the Study:
- To investigate the association between infant pertussis immunization and asthma medication use in adolescence.
Main Methods:
- A follow-up study compared asthma medication data in nearly 80,000 pertussis-vaccinated Swedish children with ~100,000 unvaccinated children.
- Data on dispensed asthma medication from 2008-2010 were analyzed using multivariate regression models.
- Intention-to-treat and per-protocol analyses were employed to assess vaccination effects.
Main Results:
- Crude odds ratios for asthma medication use in vaccinated children were 0.97 (any medication) and 0.94 (anti-inflammatory treatment).
- Adjusted odds ratios were 0.99 (any medication) and 0.97 (anti-inflammatory treatment), indicating no increased risk.
- Per-protocol analysis yielded similar results, reinforcing the findings.
Conclusions:
- Infant pertussis immunization is not associated with an increased risk of asthma medication use in adolescence.
- Pertussis vaccination in early childhood appears safe concerning long-term asthma development.
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