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Endothelial keratoplasty with infant donor tissue
Akira Kobayashi1, Hideaki Yokogawa1, Natsuko Yamazaki1
1Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Clinical Ophthalmology (Auckland, N.Z.)
|September 24, 2014
Summary
This study shows that using infant donor tissue for non-Descemet stripping automated endothelial keratoplasty (nDSAEK) can lead to excellent visual outcomes and high endothelial cell density, with minimal cell loss over one year.
Area of Science:
- Ophthalmology
- Transplantation Surgery
- Corneal Surgery
Background:
- Endothelial dysfunction can impair vision.
- Corneal transplantation, including DSAEK/nDSAEK, is a treatment option.
- Infant donor tissue is rarely used for endothelial keratoplasty.
Observation:
- A 52-year-old male received nDSAEK using 2-year-old infant donor tissue.
- The infant donor tissue was noted to be exceptionally elastic and soft.
- A double-glide technique facilitated successful insertion of the 8.0 mm donor tissue.
Findings:
- Preoperative endothelial cell density was 4,291 cells/mm².
- Best corrected visual acuity improved significantly from 1.7 logMAR to 0.1 logMAR at 1 year.
- Endothelial cell density remained high at 4,032 cells/mm² (6.0% loss) after 1 year.
Implications:
- Infant donor tissue is a viable option for DSAEK/nDSAEK.
- This approach offers excellent visual rehabilitation and donor cell survival.
- Infant tissue may be less suitable for other keratoplasty types.