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Updated: Apr 23, 2026

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
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Perfusion magnetic resonance imaging: a comprehensive update on principles and techniques

Geon-Ho Jahng1, Ka-Loh Li2, Leif Ostergaard3

  • 1Department of Radiology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul 134-727, Korea.

Korean Journal of Radiology
|September 24, 2014
PubMed

Insights

Perfusion MRI measures blood flow to tissues, aiding in disease diagnosis like tumors and stroke. This review details MRI perfusion principles and techniques, highlighting methods with and without contrast agents.

Area of Science:

  • Medical Imaging
  • Physiology
  • Biophysics

Background:

  • Perfusion, the delivery of oxygen and nutrients via blood flow, is vital for tissue health.
  • Perfusion MRI is a sensitive imaging technique for microvasculature, with applications in tumor classification, stroke identification, and disease characterization.
  • MRI-based perfusion measurements are minimally invasive, avoiding radiation and radioisotopes.

Purpose of the Study:

  • To review the fundamental principles and techniques of perfusion MRI.
  • To provide updated knowledge on the physical principles and methodologies of perfusion MRI.

Main Methods:

  • Classification of perfusion MRI techniques into those with and without exogenous contrast agents.
  • Description of bolus tracking methods using contrast agents for enhanced sensitivity and spatial resolution.
  • Explanation of arterial spin-labeling methods for contrast-agent-free cerebral blood flow quantification.

Main Results:

  • Perfusion MRI offers insights into microvasculature crucial for diagnosing various diseases.
  • Bolus methods provide high sensitivity and resolution, making them clinically prevalent.
  • Arterial spin-labeling enables accurate, contrast-agent-free quantification of cerebral blood flow.

Conclusions:

  • Perfusion MRI is a versatile and minimally invasive diagnostic tool.
  • Understanding the principles and techniques of different perfusion MRI methods is essential for clinical application.
  • This review synthesizes current knowledge on perfusion MRI principles and techniques.
Keywords:
Arterial spin-labelingDynamic contrast-enhancedDynamic susceptibility contrastPerfusionPerfusion MRI

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