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Published on: June 7, 2012
The effects of soy extract on spatial learning and memory damage induced by global ischemia in ovariectomised rats
Farzaneh Vafaee1, Mahmoud Hosseini2, Hamid Reza Sadeghinia3
1Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Postal Code 9177948564, Iran.
Background:
The effects of soy extract on memory as well as the oxidative damage to brain tissue induced by ischemia was investigated in ovariectomised (OVX) rats.
Methods:
THE RATS WERE DIVIDED INTO: 1) Sham; 2) OVX; 3) Sham‑Ischemia; 4) OVX‑Ischemia; 5) OVX-Ischemia-S 20; and 6) OVX-Ischemia-S 60. The common carotid artery was occluded (30 minutes), and it was then re-perfused. The OVX-Ischemia-S 20 and OVX-Ischemia-S 60 groups received 20 or 60 mg/kg of soy extract for eight weeks before the ischemia.
Results:
The Sham-Ischemia and OVX-Ischemia groups took a longer time to reach the platform while, spent a shorter time in the target quadrant (Q1) than the Sham and OVX. The escape latencies in the OVX-Ischemia-S 20 and OVX-Ischemia-S 60 groups were lower while, time spent in the Q1 was higher than that of the OVX-Ischemia. In the rotarod test, there were no significant differences between the groups. The hippocampal concentrations of malondialdehyde (MDA) in the Sham-Ischemia and OVX-Ischemia groups were higher than the Sham and OVX. Pre-treatment by 20 and 60 mg/kg of the extract reduced the MDA.
Conclusion:
It is suggested that soy prevents memory impairment and brain tissue oxidative damage due to ischemia in OVX rats.
